The World Dementia Council was set up after 2013, with the aim to prevent and treat Alzheimer’s disease and other major dementias by 2025. They support the research of dementia amongst international entities and governments, focusing on the clinical trials of new drugs and genetics, amongst others. Last March 2021, the first meeting took place, where they discussed what has been done to achieve the so-called 2025 dementia goals (http://www.worlddementiacouncil.org/) In the UK, dementia research is funded by the Government, Medical Research Council, Alzheimer’s Research UK, pharmaceutical companies, and other organisations. Alzheimer’s Research UK alone has invested in more than 900 dementia projects at 106 UK and international institutions.
Research at the University of Nottingham & the Queen’s Medical Centre
Extensive research has been carried out at Nottingham for many years with ancillary funding and other types of support from the Neuroscience Support Group at the QMC. Professor Mayer, our Chairman, has a special interest in the importance of the ubiquitin-proteasome system in human chronic neurodegenerative diseases such as dementia and motor neuron diseases. “All these diseases are characterised neuropathologically by the occurrence of inclusion bodies (Lewy bodies) in neurones, containing ubiquitinated proteins”, says Professor Mayer. Current Dementia research at Nottingham (see our Projects page):
- Professor Philip Bath – Vascular dementia: Prevention and treatment of acute stroke and management of post-stroke blood pressure, dysphagia, and cognitive decline. Through preclinical studies and clinical trials.
- Associate Professor Dr Robert Dineen – Mechanistic imaging of neural effects of exercise interventions in people with dementia. The research study “Promoting Activity, Independence and Stability in Early Dementia (NIHR-funded PrAISED-2 trial)”
- Professor Rowan Harwood– Palliative and end of life care: PrAISED study (Promoting Activity, Independence and Stability in Early Dementia): help people with mild cognitive impairment or early-stage dementia to remain more independent for longer. VOICE study (Videoing to improve communication through education): improve healthcare professional’s communication skills with patients with dementia.
- Dr Helen Miranda Knight– Cognitive decline, Dementia with Lewy bodies: Epigenetic and epitranscriptomic changes which contribute to disease progression.
- Professor Kevin Morgan– Alzheimer’s disease: Contributed to the discovery of 21 of the 22 genes reported to be linked with Alzheimer’s disease. Investigate the genetic variants associated with dementia and estimate how much each one modifies the risk of developing dementia.
- Dr Virginie Sottile– Dementia: Investigate if stem cells within bone marrow could form brain cells which could lead to new therapies for dementia in future.
Other members of the Centre for Dementia at the University of Nottingham:
- Prof. Tom Dening– Head of the Centre for Dementia in the Institute of Mental Health at Nottingham
- Prof. Justine Schneider–Dementia care through the arts. Principal investigator of the Singing in Dementia study (PRESIDE) in Nottingham. Lead Investigator of the doctoral training centre, The Arts and Dementia (TAnDem). Initiator of the website IDEA (Improving Dementia Education and Awareness).
- Neil Chadborn– Geriatrics: Coordinator of the “East Midlands Research into Ageing Network (EMRAN)” NIHR ARC-EM
- Michael Craven- Technology design. Principal Research Fellow at the University of Nottingham in the NIHR MindTech MedTech Co-operative. Projects: Designing for Dementia (MinD); Brain+ AD Detect-Prevent, Cognitive testing and training app.
- Dr Orii McDermott– Technological approaches for early detection of dementia and strategies for dementia care. “Interdisciplinary Network for Dementia Using Current Technology” (INDUCT) and “Dementia, Intersectorial Strategy for Training and Innovation Network for Current Technology” (DISTINCT).
- Prof. Martin Orrell– Evaluation of the effectiveness of treatments for dementia. Awarded 7 major dementia care research grants. Cognitive Stimulation Therapy for dementia
- Prof. Kristian Pollock– Death in society: attitudes & experiences towards death and dying, place of death, Advance Care Planning, medicines management and dementia.
Further information links:
- University of Nottingham
- Centre for Dementia https://www.nottingham.ac.uk/research/groups/dementia/index.aspx
- Health of Older People, Projects https://www.nottingham.ac.uk/research/groups/healthofolderpeople/projects/index.aspx
- Training for healthcare professionals aids communication with dementia patients https://www.nihr.ac.uk/case-studies/voice-training-for-healthcare-professionals-aids-communication-with-dementia-patients/26140 VOICE study– UoN + NIHR
- Developed by the UoN—Online resource to improve the care and quality of life for people with dementia https://idea.nottingham.ac.uk/