Projects

What the NSG is currently supporting

D E M E N T I A S

  • Dr. Helen M. Knight’s group “Brain Genomics Lab at the University of Nottingham investigates epigenetic and genomic factors which contribute to cognitive decline and different forms of dementia.

Currently, the NSG@QMC is co-funding M.D Adriana PerezGrovas S’s Ph.D. project “Genomic regulation by DNA 5-carboxylcytosine (5caC), 5-formylcitosine (5fC) and RNA m5C methylation and role in cognitive diseases”.  She is an international student receiving fundings from the Mexican government’s scholarship “CONACYT” (Consejo Nacional de Ciencia y Tecnología).

She has just started her second year (2020-2023) as a Ph.D. candidate at the QMC, University of Nottingham. She joined the Brain Genomics group in February 2020 under the supervision of Dr. Helen Miranda Knight. Her Ph.D. thesis investigates epigenetic factors that contribute to dementias with the aim to understand mechanisms involved in DNA and RNA methylation processes, and how they link to protein abnormalities associated with dementia with Lewis bodies.

  • Professor Morgan’s team, the Human Genetics group, is carrying out a multi-million-pound world-class research programme that involves identifying genes involved in Dementia- 22 new genes discovered since 2009.

The NSG funds investigations by Ph.D. students into rare variations of the diseases and in particular Alzheimer’s disease. Sultan Chaudhury is a PhD candidate of Professor’s Morgan team, whose Project – SC funded by NSG – is entitled “Using the BDR Resource to understand the Genetics of Alzheimer’s”

The Brains for Dementia Research (BDR) project is an initiative funded jointly by the Alzheimer’s Society and Alzheimer’s Research UK to address the shortage of brain tissue from individuals that is essential for research into dementia (http://www.brainsfordementiaresearch.org.uk/). The BDR project engages participants that have different types of dementia as well as individuals that do not have dementia to investigate how and why dementia occurs (read more).

P A R K I N S O N ' S . D I S E A S E

For several years, the research undertaken by Professor Mayer and late Dr. Bedford has focused on gaining a greater understanding of developing what causes dementia and Parkinson’s disease with a view to the development of better forms of treatment. In particular, they have developed a model aimed at identifying why protein inclusions (Lewy bodies) build up in the brain cells of people who suffer from those diseases. The NSG has contributed significant amounts to the research projects and would like to do more to support this invaluable work.

M U L T I P L E . S C L E R O S I S

Imaging techniques are being used in projects funded by the MS Society at the University of Nottingham to investigate the cognitive changes which take place in the brains of people with MS. The NSG has secured Big Lottery funding to promote awareness of MS and is also considering the possibility of funding a project to determine the extent to which a drug used for other purposes might assist in the treatment of MS.

O T H E R - P R O J E C T S

Role of Protein misfolding in Neuronal Death.

Anya Snary (Supervisor Tom Bellamy)

 

Fluorescent Live Imaging Platform

¨Molecular mechanisms in neuronal communication and its degeneration¨

Federico Dajas-Bailador and Sebastien Serres